Lipolysis

benson_diagram.jpg
Protein kinase lipase hydrolyzes esterbonds from triglyceride to release Glycerol and Fatty Acids. Bukowiecki L.,(1980) AJP-ENDO.239(6), E422-E429

Lipolysis involves the subsequent break down of triglycerides into diglycerides, monoglycerides, glycerol and FFA (free fatty acids). [1]

When this process is complete, one molecule of glycerol and three molecules of FAs are produced by the hydrolysis. Ideally this occurs at a 3:1 ratio but it does not because some FAs are re-utlized by the fat cells, they are re-esterified, mediated by glycerol kinase, into new triglycerides. By the FFA/Triglyceride Cycle. Lipolysis is induced by epinephrine, norepinephrine, glucagon, growth hormone, testostrone, and cortisol. [2] Caffeine causes a cascade of activation which ultimately increases lipolysis. [3]

Triglyceride.png
Triglycerate Molecule drawn by Tennison Yu



Pathway 1
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  1. ^ Bukowiecki, L.(1980). AJP-ENDO. 239(6), E422-E429
  2. ^ Arner, P. (2005). Best Practice & Research Clinical Endocrinology & Metabolism.19, 471-482.
  3. ^ Hursel, R., Westerterp-Plantenga, M.S., (2010) International Journal of Obesity. 34, 659-669